Robert Sanchez is back in goal, while Liam Rosenior has made changes in defence, bringing Trevoh Chalobah and Marc Cucurella into the lineup. Reece James is likely to move to right-back, with Benoit Badiashile completing the back four.
In midfield, Andrey Santos partners Moises Caicedo. Enzo Fernandez continues in the no.10 position, supported by Pedro Neto and Estevao Willian on the flanks. Joao Pedro leads the attack.
The bench features goalkeeper Teddy Sharman-Lowe, while Cole Palmer is absent from the matchday squad. For Crystal Palace, Daniel Munoz and Ismaila Sarr return after missing games since last month.
Chelsea starting XI: Sanchez; James (c), Chalobah, Badiashile, Cucurella; Andrey Santos, Caicedo; Estevao Willian, Fernandez, Neto; Joao Pedro
Chelsea substitutes: Sharman-Lowe, Acheampong, Gusto, Fofana, Hato, Garnacho, Gittens, Delap, Guiu
Crystal Palace starting XI: Henderson, Richards, Lacroix, Canvot, Munoz, Lerma, Wharton, Mitchell, Sarr, Johnson, Mateta
Crystal Palace substitutes: Benitez, Riad, Sosa, Imray, Rodney, Devenny, Hughes, Pino, Uche
Referee: Darren England
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